Drug interactions
Crizotinib + Cyclophosphamide
Severity: Minor
Crizotinib and Cyclophosphamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclophosphamide is not a clinically established inhibitor of aldehyde dehydrogenase in a way that would raise crizotinib levels, and crizotinib is cleared mainly by CYP3A. Any pharmacokinetic interaction is therefore speculative.
What this interaction means in plain words
Crizotinib and Cyclophosphamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crizotinib belongs to Oncology; Cyclophosphamide belongs to Oncology.
Why it happens
No well-established mechanism; the proposed aldehyde dehydrogenase effect is theoretical.
What to do
No dose adjustment is needed. Monitor for the usual crizotinib adverse effects such as hepatotoxicity and cytopenias.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclophosphamide
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Cyclophosphamide?
MediHelp rates the interaction as minor. Crizotinib and Cyclophosphamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyclophosphamide is not a clinically established inhibitor of aldehyde dehydrogenase in a way that would raise crizotinib levels, and crizotinib is cleared mainly by CYP3A. Any pharmacokinetic interaction is therefore speculative.
How serious is the interaction between Crizotinib and Cyclophosphamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for the usual crizotinib adverse effects such as hepatotoxicity and cytopenias.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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