Drug interactions
Crizotinib + Cyclosporin
Severity: Major
Crizotinib and Cyclosporin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib inhibits CYP3A4 and may raise cyclosporine concentrations, while cyclosporine may in turn raise crizotinib exposure. Because cyclosporine has a narrow therapeutic index, this can result in nephrotoxicity or other toxicity.
What this interaction means in plain words
Crizotinib and Cyclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Crizotinib belongs to Oncology; Cyclosporin belongs to Miscellaneous.
Why it happens
Mutual inhibition of CYP3A4 metabolism by crizotinib and cyclosporine.
What to do
Avoid if possible; if used together, monitor cyclosporine trough levels and renal function frequently and watch for crizotinib adverse effects such as QT prolongation and hepatotoxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Cyclosporin?
MediHelp rates the interaction as major. Crizotinib and Cyclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Crizotinib inhibits CYP3A4 and may raise cyclosporine concentrations, while cyclosporine may in turn raise crizotinib exposure. Because cyclosporine has a narrow therapeutic index, this can result in nephrotoxicity or other toxicity.
How serious is the interaction between Crizotinib and Cyclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if used together, monitor cyclosporine trough levels and renal function frequently and watch for crizotinib adverse effects such as QT prolongation and hepatotoxicity.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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