Drug interactions
Crizotinib + Dabigatran etexilate
Severity: Moderate
Crizotinib and Dabigatran etexilate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib can inhibit P-glycoprotein and may increase dabigatran absorption and exposure. This could heighten bleeding risk, particularly in patients with reduced renal function.
What this interaction means in plain words
Crizotinib and Dabigatran etexilate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Dabigatran etexilate belongs to Cardiovascular.
Why it happens
Inhibition of intestinal P-glycoprotein efflux of dabigatran etexilate.
What to do
Monitor for bleeding and check renal function regularly. Consider an alternative anticoagulant if renal function is significantly impaired.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Dabigatran etexilate?
MediHelp rates the interaction as moderate. Crizotinib and Dabigatran etexilate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib can inhibit P-glycoprotein and may increase dabigatran absorption and exposure. This could heighten bleeding risk, particularly in patients with reduced renal function.
How serious is the interaction between Crizotinib and Dabigatran etexilate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and check renal function regularly. Consider an alternative anticoagulant if renal function is significantly impaired.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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