Drug interactions
Crizotinib + Daunorubicin
Severity: Moderate
Crizotinib and Daunorubicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib may inhibit P-glycoprotein, which could raise daunorubicin exposure. This could worsen myelosuppression and cardiotoxicity, though clinical data are limited.
What this interaction means in plain words
Crizotinib and Daunorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Daunorubicin belongs to Oncology.
Why it happens
Inhibition of P-glycoprotein efflux of daunorubicin by crizotinib.
What to do
Monitor blood counts and cardiac function. Consider daunorubicin dose adjustment if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Daunorubicin
- Adenovirus types 4 and 7 live + Daunorubicin Contraindicated
- Belatacept + Daunorubicin Major
- Cyclosporin + Daunorubicin Major
- Daunorubicin + Dengue vaccine Major
- Daunorubicin + Etrasimod Major
- Daunorubicin + Fingolimod Major
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Daunorubicin?
MediHelp rates the interaction as moderate. Crizotinib and Daunorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib may inhibit P-glycoprotein, which could raise daunorubicin exposure. This could worsen myelosuppression and cardiotoxicity, though clinical data are limited.
How serious is the interaction between Crizotinib and Daunorubicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function. Consider daunorubicin dose adjustment if toxicity develops.
What other medicines interact with Daunorubicin?
MediHelp also lists interactions of Daunorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclosporin. The full list is on the Daunorubicin page.
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