Drug interactions
Crizotinib + Deflazacort
Severity: Moderate
Crizotinib and Deflazacort: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib is a moderate CYP3A4 inhibitor and raises exposure to the active metabolite of deflazacort. This may increase corticosteroid adverse effects such as infection, hyperglycemia and adrenal suppression.
What this interaction means in plain words
Crizotinib and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Deflazacort belongs to Miscellaneous.
Why it happens
Crizotinib inhibits CYP3A4, reducing clearance of deflazacort's active metabolite.
What to do
Reduce deflazacort to about one-third of the usual dose while crizotinib is given, per labeling. Monitor for corticosteroid toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Crizotinib with Deflazacort?
MediHelp rates the interaction as moderate. Crizotinib and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib is a moderate CYP3A4 inhibitor and raises exposure to the active metabolite of deflazacort. This may increase corticosteroid adverse effects such as infection, hyperglycemia and adrenal suppression.
How serious is the interaction between Crizotinib and Deflazacort?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce deflazacort to about one-third of the usual dose while crizotinib is given, per labeling. Monitor for corticosteroid toxicity.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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