Drug interactions
Crizotinib + Dexamethasone
Severity: Moderate
Crizotinib and Dexamethasone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone induces CYP3A4 and may reduce crizotinib exposure, while crizotinib inhibits CYP3A4 and may raise dexamethasone exposure. The two effects partly oppose each other and the net outcome is uncertain.
What this interaction means in plain words
Crizotinib and Dexamethasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Dexamethasone belongs to Endocrine.
Why it happens
Bidirectional CYP3A4 effects: induction by dexamethasone and time-dependent inhibition by crizotinib.
What to do
Monitor for reduced crizotinib efficacy and for corticosteroid adverse effects; adjust doses based on clinical response and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Dexamethasone?
MediHelp rates the interaction as moderate. Crizotinib and Dexamethasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone induces CYP3A4 and may reduce crizotinib exposure, while crizotinib inhibits CYP3A4 and may raise dexamethasone exposure. The two effects partly oppose each other and the net outcome is uncertain.
How serious is the interaction between Crizotinib and Dexamethasone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced crizotinib efficacy and for corticosteroid adverse effects; adjust doses based on clinical response and tolerability.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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