Drug interactions
Crizotinib + Docetaxel
Severity: Moderate
Crizotinib and Docetaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib inhibits CYP3A4 and P-glycoprotein and may raise docetaxel exposure. This can increase neutropenia, fluid retention and neuropathy.
What this interaction means in plain words
Crizotinib and Docetaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Docetaxel belongs to Oncology.
Why it happens
Crizotinib inhibits CYP3A4 and P-glycoprotein, reducing docetaxel clearance.
What to do
Monitor neutrophil counts and toxicity closely and reduce docetaxel dose if severe adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Docetaxel
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Docetaxel?
MediHelp rates the interaction as moderate. Crizotinib and Docetaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib inhibits CYP3A4 and P-glycoprotein and may raise docetaxel exposure. This can increase neutropenia, fluid retention and neuropathy.
How serious is the interaction between Crizotinib and Docetaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts and toxicity closely and reduce docetaxel dose if severe adverse effects develop.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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