Drug interactions
Crizotinib + Erdafitinib
Severity: Moderate
Crizotinib and Erdafitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib inhibits P-glycoprotein and may raise concentrations of P-gp substrates such as crizotinib. This could increase crizotinib adverse effects including hepatotoxicity and QT prolongation.
What this interaction means in plain words
Crizotinib and Erdafitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Erdafitinib belongs to Oncology.
Why it happens
Erdafitinib inhibits P-glycoprotein efflux, increasing crizotinib absorption and exposure.
What to do
If coadministration is needed, separate crizotinib dosing from erdafitinib by at least 6 hours and monitor for crizotinib toxicity and ECG changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Erdafitinib
Frequently asked questions
Can I take Crizotinib with Erdafitinib?
MediHelp rates the interaction as moderate. Crizotinib and Erdafitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erdafitinib inhibits P-glycoprotein and may raise concentrations of P-gp substrates such as crizotinib. This could increase crizotinib adverse effects including hepatotoxicity and QT prolongation.
How serious is the interaction between Crizotinib and Erdafitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If coadministration is needed, separate crizotinib dosing from erdafitinib by at least 6 hours and monitor for crizotinib toxicity and ECG changes.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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