Drug interactions
Crizotinib + Ifosfamide
Severity: Moderate
Crizotinib and Ifosfamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib inhibits CYP3A4 and could reduce the conversion of ifosfamide to its active metabolites, potentially lowering efficacy. It may also reduce formation of toxic chloroacetaldehyde, so net clinical effect is uncertain.
What this interaction means in plain words
Crizotinib and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Ifosfamide belongs to Oncology.
Why it happens
Crizotinib inhibition of CYP3A4-mediated ifosfamide activation and dechloroethylation.
What to do
Monitor treatment response and toxicity. Consider an alternative to the CYP3A4 inhibitor if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Ifosfamide?
MediHelp rates the interaction as moderate. Crizotinib and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib inhibits CYP3A4 and could reduce the conversion of ifosfamide to its active metabolites, potentially lowering efficacy. It may also reduce formation of toxic chloroacetaldehyde, so net clinical effect is uncertain.
How serious is the interaction between Crizotinib and Ifosfamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor treatment response and toxicity. Consider an alternative to the CYP3A4 inhibitor if feasible.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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