Drug interactions
Crizotinib + Irinotecan
Severity: Moderate
Crizotinib and Irinotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib is a moderate CYP3A inhibitor and may raise concentrations of irinotecan or its active metabolite SN-38. This may increase the risk of neutropenia and diarrhoea.
What this interaction means in plain words
Crizotinib and Irinotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Irinotecan belongs to Oncology.
Why it happens
Crizotinib inhibits CYP3A4, reducing the metabolism of irinotecan to inactive oxidized metabolites.
What to do
Monitor blood counts and gastrointestinal toxicity closely and reduce the irinotecan dose or delay treatment if severe diarrhoea or neutropenia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Irinotecan?
MediHelp rates the interaction as moderate. Crizotinib and Irinotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib is a moderate CYP3A inhibitor and may raise concentrations of irinotecan or its active metabolite SN-38. This may increase the risk of neutropenia and diarrhoea.
How serious is the interaction between Crizotinib and Irinotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and gastrointestinal toxicity closely and reduce the irinotecan dose or delay treatment if severe diarrhoea or neutropenia develops.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
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