Drug interactions
Crizotinib + Isoflurane
Severity: Moderate
Crizotinib and Isoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib prolongs the QT interval and can cause bradycardia, and volatile anesthetics can add to QT prolongation. This increases the risk of torsades de pointes during surgery.
What this interaction means in plain words
Crizotinib and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Isoflurane belongs to Central Nervous System.
Why it happens
Additive QT prolongation.
What to do
Review baseline QTc and electrolytes before anesthesia and monitor the ECG during the procedure. Discuss temporarily holding crizotinib with the oncologist if QTc is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoflurane
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Isoflurane?
MediHelp rates the interaction as moderate. Crizotinib and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib prolongs the QT interval and can cause bradycardia, and volatile anesthetics can add to QT prolongation. This increases the risk of torsades de pointes during surgery.
How serious is the interaction between Crizotinib and Isoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review baseline QTc and electrolytes before anesthesia and monitor the ECG during the procedure. Discuss temporarily holding crizotinib with the oncologist if QTc is prolonged.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
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