Drug interactions
Crizotinib + Larotrectinib
Severity: Moderate
Crizotinib and Larotrectinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib is a CYP3A4 inhibitor, which would be expected to increase, not decrease, larotrectinib exposure. Higher larotrectinib levels may increase its adverse effects such as hepatotoxicity and neurotoxicity.
What this interaction means in plain words
Crizotinib and Larotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Larotrectinib belongs to Oncology.
Why it happens
Crizotinib inhibits CYP3A4, the main enzyme metabolizing larotrectinib.
What to do
Avoid if possible; otherwise monitor liver enzymes and neurologic effects and consider reducing the larotrectinib dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Larotrectinib
Frequently asked questions
Can I take Crizotinib with Larotrectinib?
MediHelp rates the interaction as moderate. Crizotinib and Larotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib is a CYP3A4 inhibitor, which would be expected to increase, not decrease, larotrectinib exposure. Higher larotrectinib levels may increase its adverse effects such as hepatotoxicity and neurotoxicity.
How serious is the interaction between Crizotinib and Larotrectinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor liver enzymes and neurologic effects and consider reducing the larotrectinib dose.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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