Drug interactions
Crizotinib + Lefamulin
Severity: Major
Crizotinib and Lefamulin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and lefamulin is a CYP3A inhibitor that may increase crizotinib exposure, further adding to the risk. This raises the potential for torsades de pointes.
What this interaction means in plain words
Crizotinib and Lefamulin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Crizotinib belongs to Oncology; Lefamulin belongs to Anti Bacterial.
Why it happens
Additive QT prolongation combined with lefamulin inhibition of CYP3A4-mediated crizotinib metabolism.
What to do
Avoid the combination where possible, particularly with oral lefamulin, which is contraindicated with QT-prolonging CYP3A substrates. If unavoidable, monitor ECG and electrolytes closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Crizotinib with Lefamulin?
MediHelp rates the interaction as major. Crizotinib and Lefamulin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and lefamulin is a CYP3A inhibitor that may increase crizotinib exposure, further adding to the risk. This raises the potential for torsades de pointes.
How serious is the interaction between Crizotinib and Lefamulin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, particularly with oral lefamulin, which is contraindicated with QT-prolonging CYP3A substrates. If unavoidable, monitor ECG and electrolytes closely.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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