Drug interactions
Crizotinib + Mavacamten
Severity: Major
Crizotinib and Mavacamten: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib may increase mavacamten exposure, which can excessively reduce ejection fraction and cause heart failure.
What this interaction means in plain words
Crizotinib and Mavacamten can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Crizotinib belongs to Oncology; Mavacamten belongs to Cardiovascular.
Why it happens
Crizotinib inhibits CYP3A4 (and partly CYP2C19-independent pathways) metabolism of mavacamten, raising its levels.
What to do
Monitor LVEF by echocardiography and adjust mavacamten per labeling when starting or stopping crizotinib. Watch for heart failure symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Crizotinib with Mavacamten?
MediHelp rates the interaction as major. Crizotinib and Mavacamten can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Crizotinib may increase mavacamten exposure, which can excessively reduce ejection fraction and cause heart failure.
How serious is the interaction between Crizotinib and Mavacamten?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor LVEF by echocardiography and adjust mavacamten per labeling when starting or stopping crizotinib. Watch for heart failure symptoms.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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