Drug interactions
Crizotinib + Nelfinavir
Severity: Major
Crizotinib and Nelfinavir: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir is a strong CYP3A4 inhibitor and increases crizotinib concentrations, raising the risk of QT prolongation, bradycardia and hepatotoxicity. Crizotinib may also modestly increase nelfinavir exposure through P-glycoprotein inhibition.
What this interaction means in plain words
Crizotinib and Nelfinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Crizotinib belongs to Oncology; Nelfinavir belongs to Anti Virals.
Why it happens
Nelfinavir inhibits CYP3A4 metabolism of crizotinib, and crizotinib may inhibit P-glycoprotein efflux of nelfinavir.
What to do
Avoid concurrent use if possible; if necessary, reduce the crizotinib dose per labeling and monitor ECG, electrolytes and liver enzymes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Crizotinib with Nelfinavir?
MediHelp rates the interaction as major. Crizotinib and Nelfinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nelfinavir is a strong CYP3A4 inhibitor and increases crizotinib concentrations, raising the risk of QT prolongation, bradycardia and hepatotoxicity. Crizotinib may also modestly increase nelfinavir exposure through P-glycoprotein inhibition.
How serious is the interaction between Crizotinib and Nelfinavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if possible; if necessary, reduce the crizotinib dose per labeling and monitor ECG, electrolytes and liver enzymes.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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