Drug interactions
Crizotinib + Norgestrel
Severity: Minor
Crizotinib and Norgestrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib inhibits CYP3A4 and may modestly increase norgestrel concentrations. This could increase progestin-related adverse effects, although the clinical effect is usually limited.
What this interaction means in plain words
Crizotinib and Norgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crizotinib belongs to Oncology; Norgestrel belongs to Endocrine.
Why it happens
Crizotinib inhibits CYP3A4, reducing metabolism of norgestrel.
What to do
No routine dose change is needed; monitor for progestogenic adverse effects such as bleeding changes, headache or fluid retention.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Norgestrel
- Amobarbital + Norgestrel Major
- Apalutamide + Norgestrel Major
- Bosentan + Norgestrel Major
- Carbamazepine + Norgestrel Major
- Efavirenz + Norgestrel Major
- Enzalutamide + Norgestrel Major
Frequently asked questions
Can I take Crizotinib with Norgestrel?
MediHelp rates the interaction as minor. Crizotinib and Norgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crizotinib inhibits CYP3A4 and may modestly increase norgestrel concentrations. This could increase progestin-related adverse effects, although the clinical effect is usually limited.
How serious is the interaction between Crizotinib and Norgestrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for progestogenic adverse effects such as bleeding changes, headache or fluid retention.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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