Drug interactions
Crizotinib + Nortriptyline
Severity: Major
Crizotinib and Nortriptyline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib and nortriptyline both can prolong the QT interval, and crizotinib may also cause bradycardia. Combined use could raise the risk of torsades de pointes.
What this interaction means in plain words
Crizotinib and Nortriptyline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Crizotinib belongs to Oncology; Nortriptyline belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation, with crizotinib-related bradycardia increasing risk.
What to do
Avoid combining if possible; otherwise monitor ECG and electrolytes at baseline and periodically, and reduce or stop treatment if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Nortriptyline?
MediHelp rates the interaction as major. Crizotinib and Nortriptyline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Crizotinib and nortriptyline both can prolong the QT interval, and crizotinib may also cause bradycardia. Combined use could raise the risk of torsades de pointes.
How serious is the interaction between Crizotinib and Nortriptyline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining if possible; otherwise monitor ECG and electrolytes at baseline and periodically, and reduce or stop treatment if QTc becomes markedly prolonged.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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