Drug interactions
Crizotinib + Palifermin
Severity: Minor
Crizotinib and Palifermin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palifermin stimulates epithelial cell growth and may worsen mucositis if given close to cytotoxic therapy. This warning is based on cytotoxic chemotherapy, and its relevance to oral crizotinib is unclear.
What this interaction means in plain words
Crizotinib and Palifermin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crizotinib belongs to Oncology; Palifermin belongs to Miscellaneous.
Why it happens
Not established for crizotinib; the concern is stimulated proliferation of epithelium exposed to cytotoxic agents.
What to do
Palifermin is mainly used with myelotoxic chemotherapy; no specific adjustment is established for crizotinib. Monitor for mucositis if both are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Palifermin
Frequently asked questions
Can I take Crizotinib with Palifermin?
MediHelp rates the interaction as minor. Crizotinib and Palifermin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Palifermin stimulates epithelial cell growth and may worsen mucositis if given close to cytotoxic therapy. This warning is based on cytotoxic chemotherapy, and its relevance to oral crizotinib is unclear.
How serious is the interaction between Crizotinib and Palifermin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Palifermin is mainly used with myelotoxic chemotherapy; no specific adjustment is established for crizotinib. Monitor for mucositis if both are used.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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