Drug interactions
Crizotinib + Palovarotene
Severity: Major
Crizotinib and Palovarotene: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib may increase palovarotene exposure, raising retinoid toxicity such as mucocutaneous effects and premature growth plate closure.
What this interaction means in plain words
Crizotinib and Palovarotene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Crizotinib belongs to Oncology; Palovarotene belongs to Miscellaneous.
Why it happens
Crizotinib inhibits CYP3A4 metabolism of palovarotene.
What to do
Avoid combination; if unavoidable, reduce palovarotene by 50% and monitor for retinoid adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Palovarotene
- Acitretin + Palovarotene Contraindicated
- Isotretinoin + Palovarotene Contraindicated
- Amiodarone + Palovarotene Major
- Amobarbital + Palovarotene Major
- Apalutamide + Palovarotene Major
- Aprepitant + Palovarotene Major
Frequently asked questions
Can I take Crizotinib with Palovarotene?
MediHelp rates the interaction as major. Crizotinib and Palovarotene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Crizotinib may increase palovarotene exposure, raising retinoid toxicity such as mucocutaneous effects and premature growth plate closure.
How serious is the interaction between Crizotinib and Palovarotene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination; if unavoidable, reduce palovarotene by 50% and monitor for retinoid adverse effects.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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