Drug interactions
Crizotinib + Pantoprazole
Severity: Minor
Crizotinib and Pantoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib solubility is pH-dependent, so acid suppression could theoretically reduce its absorption. No formal studies show a clinically meaningful loss of effect.
What this interaction means in plain words
Crizotinib and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crizotinib belongs to Oncology; Pantoprazole belongs to Gastrointestinal Tract.
Why it happens
Raised gastric pH may decrease crizotinib dissolution and absorption.
What to do
No routine change is needed; monitor treatment response if a proton pump inhibitor is necessary.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Frequently asked questions
Can I take Crizotinib with Pantoprazole?
MediHelp rates the interaction as minor. Crizotinib and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crizotinib solubility is pH-dependent, so acid suppression could theoretically reduce its absorption. No formal studies show a clinically meaningful loss of effect.
How serious is the interaction between Crizotinib and Pantoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor treatment response if a proton pump inhibitor is necessary.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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