Drug interactions
Crizotinib + Ponesimod
Severity: Major
Crizotinib and Ponesimod: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can slow the heart rate, and both have QT-prolonging potential. Combined use may cause additive bradycardia and conduction or arrhythmic effects.
What this interaction means in plain words
Crizotinib and Ponesimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Crizotinib belongs to Oncology; Ponesimod belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic bradycardia and QT prolongation.
What to do
Avoid starting ponesimod in patients on crizotinib unless benefit outweighs risk, and seek cardiology advice. If used together, monitor heart rate and ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Ponesimod
- Fingolimod + Ponesimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Amiodarone + Ponesimod Major
- Amisulpride + Ponesimod Major
- Anagrelide + Ponesimod Major
- Anti-thymocyte + Ponesimod Major
Frequently asked questions
Can I take Crizotinib with Ponesimod?
MediHelp rates the interaction as major. Crizotinib and Ponesimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can slow the heart rate, and both have QT-prolonging potential. Combined use may cause additive bradycardia and conduction or arrhythmic effects.
How serious is the interaction between Crizotinib and Ponesimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting ponesimod in patients on crizotinib unless benefit outweighs risk, and seek cardiology advice. If used together, monitor heart rate and ECG.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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