Drug interactions
Crizotinib + Praziquantel
Severity: Moderate
Crizotinib and Praziquantel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib may raise praziquantel exposure because it inhibits CYP3A4, a main route of praziquantel metabolism. Higher levels could increase dose-related adverse effects such as dizziness, drowsiness and gastrointestinal upset.
What this interaction means in plain words
Crizotinib and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Praziquantel belongs to Anti Parasitic.
Why it happens
Crizotinib is a moderate CYP3A4 inhibitor and reduces the metabolic clearance of praziquantel.
What to do
Monitor for increased praziquantel adverse effects, especially CNS effects. Advise patients about caution with driving while both are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Praziquantel
- Enzalutamide + Praziquantel Contraindicated
- Praziquantel + Rifampin Contraindicated
- Amobarbital + Praziquantel Major
- Apalutamide + Praziquantel Major
- Butabarbital + Praziquantel Major
- Butalbital + Praziquantel Major
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Praziquantel?
MediHelp rates the interaction as moderate. Crizotinib and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib may raise praziquantel exposure because it inhibits CYP3A4, a main route of praziquantel metabolism. Higher levels could increase dose-related adverse effects such as dizziness, drowsiness and gastrointestinal upset.
How serious is the interaction between Crizotinib and Praziquantel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased praziquantel adverse effects, especially CNS effects. Advise patients about caution with driving while both are used.
What other medicines interact with Praziquantel?
MediHelp also lists interactions of Praziquantel with, for example, Enzalutamide, Rifampin, Amobarbital. The full list is on the Praziquantel page.
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