Drug interactions
Crizotinib + Repaglinide
Severity: Moderate
Crizotinib and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib inhibits CYP3A4 and may raise repaglinide levels, increasing the risk of hypoglycemia. Repaglinide is also cleared by CYP2C8, which limits the effect somewhat.
What this interaction means in plain words
Crizotinib and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Repaglinide belongs to Endocrine.
Why it happens
Crizotinib inhibits CYP3A4, reducing repaglinide metabolism.
What to do
Monitor blood glucose closely when starting crizotinib and consider lowering the repaglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Repaglinide?
MediHelp rates the interaction as moderate. Crizotinib and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib inhibits CYP3A4 and may raise repaglinide levels, increasing the risk of hypoglycemia. Repaglinide is also cleared by CYP2C8, which limits the effect somewhat.
How serious is the interaction between Crizotinib and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting crizotinib and consider lowering the repaglinide dose if hypoglycemia occurs.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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