Drug interactions
Crizotinib + Salbutamol
Severity: Moderate
Crizotinib and Salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib can prolong the QT interval and cause bradycardia, and salbutamol may add to QT prolongation and cause hypokalemia, mainly at high or systemic doses. The combination may raise the risk of ventricular arrhythmia in susceptible patients.
What this interaction means in plain words
Crizotinib and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Salbutamol belongs to Respiratory.
Why it happens
Additive QT prolongation, with beta-2 agonist-induced hypokalemia as a contributing factor.
What to do
Check baseline and periodic ECG and electrolytes, correcting potassium and magnesium, when salbutamol is used regularly or at high doses with crizotinib. Occasional inhaled use usually needs no change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Salbutamol?
MediHelp rates the interaction as moderate. Crizotinib and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib can prolong the QT interval and cause bradycardia, and salbutamol may add to QT prolongation and cause hypokalemia, mainly at high or systemic doses. The combination may raise the risk of ventricular arrhythmia in susceptible patients.
How serious is the interaction between Crizotinib and Salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline and periodic ECG and electrolytes, correcting potassium and magnesium, when salbutamol is used regularly or at high doses with crizotinib. Occasional inhaled use usually needs no change.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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