Drug interactions
Crizotinib + Selpercatinib
Severity: Major
Crizotinib and Selpercatinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combination raises the risk of torsades de pointes. Selpercatinib also weakly inhibits CYP3A4, which may add to crizotinib exposure.
What this interaction means in plain words
Crizotinib and Selpercatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Crizotinib belongs to Oncology; Selpercatinib belongs to Oncology.
Why it happens
Additive QT prolongation, with possible CYP3A4 inhibition by selpercatinib.
What to do
Monitor ECG, potassium, magnesium and calcium at baseline and regularly, and interrupt or reduce doses if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Selpercatinib
Frequently asked questions
Can I take Crizotinib with Selpercatinib?
MediHelp rates the interaction as major. Crizotinib and Selpercatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so combination raises the risk of torsades de pointes. Selpercatinib also weakly inhibits CYP3A4, which may add to crizotinib exposure.
How serious is the interaction between Crizotinib and Selpercatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, potassium, magnesium and calcium at baseline and regularly, and interrupt or reduce doses if QTc becomes markedly prolonged.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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