Drug interactions
Crizotinib + Tadalafil
Severity: Moderate
Crizotinib and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib is a moderate CYP3A4 inhibitor and can increase tadalafil concentrations. This may intensify headache, flushing, hypotension and other PDE5-related effects.
What this interaction means in plain words
Crizotinib and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Tadalafil belongs to Genitourinary.
Why it happens
Crizotinib inhibits CYP3A4, the main enzyme clearing tadalafil.
What to do
Start with a lower tadalafil dose and monitor blood pressure and tolerability. Avoid tadalafil initiation for pulmonary hypertension without dose review while on crizotinib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Tadalafil?
MediHelp rates the interaction as moderate. Crizotinib and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib is a moderate CYP3A4 inhibitor and can increase tadalafil concentrations. This may intensify headache, flushing, hypotension and other PDE5-related effects.
How serious is the interaction between Crizotinib and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a lower tadalafil dose and monitor blood pressure and tolerability. Avoid tadalafil initiation for pulmonary hypertension without dose review while on crizotinib.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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