Drug interactions
Crizotinib + Tolvaptan
Severity: Minor
Crizotinib and Tolvaptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib may inhibit P-glycoprotein and raise tolvaptan concentrations, increasing aquaretic effects and the risk of overly rapid sodium correction. The clinical significance is uncertain.
What this interaction means in plain words
Crizotinib and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crizotinib belongs to Oncology; Tolvaptan belongs to Endocrine.
Why it happens
Possible inhibition of P-glycoprotein efflux of tolvaptan by crizotinib.
What to do
Monitor serum sodium and fluid status during therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Crizotinib with Tolvaptan?
MediHelp rates the interaction as minor. Crizotinib and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crizotinib may inhibit P-glycoprotein and raise tolvaptan concentrations, increasing aquaretic effects and the risk of overly rapid sodium correction. The clinical significance is uncertain.
How serious is the interaction between Crizotinib and Tolvaptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium and fluid status during therapy.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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