Drug interactions
Crizotinib + Topotecan
Severity: Moderate
Crizotinib and Topotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib may inhibit P-glycoprotein and could raise topotecan exposure, particularly oral topotecan, increasing myelosuppression. The interaction is predicted rather than well documented.
What this interaction means in plain words
Crizotinib and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Topotecan belongs to Oncology.
Why it happens
P-glycoprotein inhibition by crizotinib reduces topotecan efflux and increases absorption and exposure.
What to do
Avoid with oral topotecan. With IV topotecan, monitor blood counts closely and reduce dose if neutropenia is severe.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporin + Topotecan Major
- Darunavir + Topotecan Major
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Topotecan?
MediHelp rates the interaction as moderate. Crizotinib and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib may inhibit P-glycoprotein and could raise topotecan exposure, particularly oral topotecan, increasing myelosuppression. The interaction is predicted rather than well documented.
How serious is the interaction between Crizotinib and Topotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid with oral topotecan. With IV topotecan, monitor blood counts closely and reduce dose if neutropenia is severe.
What other medicines interact with Topotecan?
MediHelp also lists interactions of Topotecan with, for example, Adenovirus types 4 and 7 live, Amiodarone, Cisplatin. The full list is on the Topotecan page.
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