Drug interactions
Crizotinib + Vinorelbine
Severity: Moderate
Crizotinib and Vinorelbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib inhibits CYP3A4 and vinorelbine is cleared mainly by CYP3A4, so vinorelbine exposure may rise. This can intensify neutropenia, neuropathy and constipation.
What this interaction means in plain words
Crizotinib and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Vinorelbine belongs to Oncology.
Why it happens
Crizotinib is a moderate CYP3A4 inhibitor that reduces hepatic and intestinal metabolism of vinorelbine.
What to do
Monitor neutrophil counts and neurotoxicity closely and reduce the vinorelbine dose if severe myelosuppression or neuropathy occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinorelbine
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Vinorelbine?
MediHelp rates the interaction as moderate. Crizotinib and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib inhibits CYP3A4 and vinorelbine is cleared mainly by CYP3A4, so vinorelbine exposure may rise. This can intensify neutropenia, neuropathy and constipation.
How serious is the interaction between Crizotinib and Vinorelbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts and neurotoxicity closely and reduce the vinorelbine dose if severe myelosuppression or neuropathy occurs.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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