Drug interactions
Crofelemer + Ethinyl estradiol-levonorgestrel
Severity: Minor
Crofelemer and Ethinyl estradiol-levonorgestrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer may inhibit CYP3A4 in the gut, but it is minimally absorbed so systemic effects are unlikely. A meaningful rise in levonorgestrel levels is improbable.
What this interaction means in plain words
Crofelemer and Ethinyl estradiol-levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crofelemer belongs to Gastrointestinal Tract; Ethinyl estradiol-levonorgestrel belongs to Endocrine.
Why it happens
Possible local intestinal CYP3A4 inhibition by crofelemer, with negligible systemic exposure.
What to do
No dose adjustment is needed. Routine awareness of progestogenic adverse effects is sufficient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Crofelemer with Ethinyl estradiol-levonorgestrel?
MediHelp rates the interaction as minor. Crofelemer and Ethinyl estradiol-levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer may inhibit CYP3A4 in the gut, but it is minimally absorbed so systemic effects are unlikely. A meaningful rise in levonorgestrel levels is improbable.
How serious is the interaction between Crofelemer and Ethinyl estradiol-levonorgestrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Routine awareness of progestogenic adverse effects is sufficient.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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