Drug interactions
Cyanocobalamin + Omeprazole
Severity: Minor
Cyanocobalamin and Omeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Long-term acid suppression reduces the release of vitamin B12 from food protein, which can lead to deficiency. Crystalline oral cyanocobalamin does not require acid for absorption, so the effect is smaller than with dietary B12.
What this interaction means in plain words
Cyanocobalamin and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyanocobalamin belongs to Miscellaneous; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Reduced gastric acid impairs protein-bound B12 release and may affect intrinsic factor-mediated uptake.
What to do
Monitor B12 status in long-term PPI users, especially elderly or at-risk patients, and continue supplementation as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Cyanocobalamin
Frequently asked questions
Can I take Cyanocobalamin with Omeprazole?
MediHelp rates the interaction as minor. Cyanocobalamin and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Long-term acid suppression reduces the release of vitamin B12 from food protein, which can lead to deficiency. Crystalline oral cyanocobalamin does not require acid for absorption, so the effect is smaller than with dietary B12.
How serious is the interaction between Cyanocobalamin and Omeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor B12 status in long-term PPI users, especially elderly or at-risk patients, and continue supplementation as needed.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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