Drug interactions
Cyclizine + Desipramine
Severity: Moderate
Cyclizine and Desipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine is an antihistamine with anticholinergic and sedative properties. With desipramine, drowsiness and anticholinergic effects such as dry mouth, tachycardia and urinary retention may be intensified.
What this interaction means in plain words
Cyclizine and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Desipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression and anticholinergic effects.
What to do
Monitor for sedation, tachycardia and anticholinergic effects, and use caution in older patients or those with urinary retention or glaucoma.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Desipramine?
MediHelp rates the interaction as moderate. Cyclizine and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclizine is an antihistamine with anticholinergic and sedative properties. With desipramine, drowsiness and anticholinergic effects such as dry mouth, tachycardia and urinary retention may be intensified.
How serious is the interaction between Cyclizine and Desipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, tachycardia and anticholinergic effects, and use caution in older patients or those with urinary retention or glaucoma.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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