Drug interactions
Cyclizine + Doxepin
Severity: Moderate
Cyclizine and Doxepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin is a tricyclic antidepressant with strong antihistaminic and anticholinergic activity. With cyclizine, sedation and anticholinergic effects are increased, causing dry mouth, constipation, urinary retention, confusion and tachycardia, especially in the elderly.
What this interaction means in plain words
Cyclizine and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Doxepin belongs to Dermatology.
Why it happens
Additive H1-receptor blockade and muscarinic antagonism.
What to do
Monitor for anticholinergic toxicity and oversedation, and consider a non-anticholinergic antiemetic in older patients. Reduce doses if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Cyclizine with Doxepin?
MediHelp rates the interaction as moderate. Cyclizine and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin is a tricyclic antidepressant with strong antihistaminic and anticholinergic activity. With cyclizine, sedation and anticholinergic effects are increased, causing dry mouth, constipation, urinary retention, confusion and tachycardia, especially in the elderly.
How serious is the interaction between Cyclizine and Doxepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and oversedation, and consider a non-anticholinergic antiemetic in older patients. Reduce doses if symptoms occur.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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