Drug interactions
Cyclizine + Flavoxate
Severity: Moderate
Cyclizine and Flavoxate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine has anticholinergic activity, so combining it with flavoxate can intensify dry mouth, blurred vision, urinary retention, constipation and drowsiness or confusion.
What this interaction means in plain words
Cyclizine and Flavoxate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Flavoxate belongs to Genitourinary.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for anticholinergic effects, particularly urinary retention and confusion in older patients. Use a non-anticholinergic antiemetic if problems arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flavoxate
- Clozapine + Flavoxate Major
- Abobotulinumtoxina + Flavoxate Moderate
- Aclidinium + Flavoxate Moderate
- Amantadine + Flavoxate Moderate
- Amitriptyline + Flavoxate Moderate
- Amoxapine + Flavoxate Moderate
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Flavoxate?
MediHelp rates the interaction as moderate. Cyclizine and Flavoxate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclizine has anticholinergic activity, so combining it with flavoxate can intensify dry mouth, blurred vision, urinary retention, constipation and drowsiness or confusion.
How serious is the interaction between Cyclizine and Flavoxate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects, particularly urinary retention and confusion in older patients. Use a non-anticholinergic antiemetic if problems arise.
What other medicines interact with Flavoxate?
MediHelp also lists interactions of Flavoxate with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Flavoxate page.
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