Drug interactions
Cyclizine + Glycopyrronium
Severity: Moderate
Cyclizine and Glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine is an antihistamine with anticholinergic activity, and combining it with glycopyrronium increases antimuscarinic adverse effects such as dry mouth, blurred vision, tachycardia and urinary retention.
What this interaction means in plain words
Cyclizine and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Glycopyrronium belongs to Respiratory.
Why it happens
Additive pharmacodynamic antimuscarinic effects.
What to do
Monitor heart rate, urinary function and cognition, especially in older patients, and consider a non-anticholinergic antiemetic if effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Glycopyrronium + Potassium chloride Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Glycopyrronium?
MediHelp rates the interaction as moderate. Cyclizine and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclizine is an antihistamine with anticholinergic activity, and combining it with glycopyrronium increases antimuscarinic adverse effects such as dry mouth, blurred vision, tachycardia and urinary retention.
How serious is the interaction between Cyclizine and Glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, urinary function and cognition, especially in older patients, and consider a non-anticholinergic antiemetic if effects occur.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Potassium chloride, Abobotulinumtoxina. The full list is on the Glycopyrronium page.
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