Drug interactions
Cyclizine + Levodopa
Severity: Moderate
Cyclizine and Levodopa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anticholinergic agents can complement levodopa in parkinsonism but may worsen dyskinesias and, at high doses, delay gastric emptying and reduce levodopa absorption. Cyclizine may also cause confusion in older patients with Parkinson disease.
What this interaction means in plain words
Cyclizine and Levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Levodopa belongs to Central Nervous System.
Why it happens
Antimuscarinic slowing of gastric emptying and pharmacodynamic modulation of cholinergic-dopaminergic balance.
What to do
Monitor motor control and dyskinesias, and watch for confusion or hallucinations. Prefer domperidone-type or non-dopamine-blocking antiemetics where nausea needs treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Other interactions of Levodopa
- Isocarboxazid + Levodopa Contraindicated
- Levodopa + Phenelzine Contraindicated
- Levodopa + Phenelzine (nonselective MAOI) Contraindicated
- Levodopa + Procarbazine Contraindicated
- Levodopa + Tranylcypromine Contraindicated
- Amisulpride + Levodopa Major
Frequently asked questions
Can I take Cyclizine with Levodopa?
MediHelp rates the interaction as moderate. Cyclizine and Levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anticholinergic agents can complement levodopa in parkinsonism but may worsen dyskinesias and, at high doses, delay gastric emptying and reduce levodopa absorption. Cyclizine may also cause confusion in older patients with Parkinson disease.
How serious is the interaction between Cyclizine and Levodopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor motor control and dyskinesias, and watch for confusion or hallucinations. Prefer domperidone-type or non-dopamine-blocking antiemetics where nausea needs treatment.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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