Drug interactions
Cyclizine + Loxapine
Severity: Moderate
Cyclizine and Loxapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine is a sedating antihistamine with anticholinergic properties. With loxapine it produces additive drowsiness and anticholinergic effects such as dry mouth, constipation, urinary retention and confusion. Cyclizine may also mask early signs of extrapyramidal effects or other adverse reactions.
What this interaction means in plain words
Cyclizine and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Loxapine belongs to Central Nervous System.
Why it happens
Additive CNS depression and antimuscarinic activity through H1 and muscarinic receptor blockade.
What to do
Monitor for oversedation and anticholinergic toxicity, particularly in older patients. Reduce the dose or choose a less sedating antiemetic if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Loxapine?
MediHelp rates the interaction as moderate. Cyclizine and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclizine is a sedating antihistamine with anticholinergic properties. With loxapine it produces additive drowsiness and anticholinergic effects such as dry mouth, constipation, urinary retention and confusion. Cyclizine may also mask early signs of extrapyramidal effects or other adverse reactions.
How serious is the interaction between Cyclizine and Loxapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and anticholinergic toxicity, particularly in older patients. Reduce the dose or choose a less sedating antiemetic if symptoms develop.
What other medicines interact with Loxapine?
MediHelp also lists interactions of Loxapine with, for example, Alfentanil, Alprazolam, Amisulpride. The full list is on the Loxapine page.
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