Drug interactions
Cyclizine + Maprotiline
Severity: Moderate
Cyclizine and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine is a sedating antihistamine with anticholinergic effects, and maprotiline shares these properties. Together they can cause excess drowsiness and anticholinergic effects such as dry mouth, constipation, urinary retention, blurred vision and confusion.
What this interaction means in plain words
Cyclizine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Maprotiline belongs to Central Nervous System.
Why it happens
Additive antimuscarinic and H1 antihistaminic CNS depressant effects.
What to do
Warn about sedation and avoid driving until tolerance is known. Monitor older patients for confusion, urinary retention and constipation, and use an alternative antiemetic if these occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Maprotiline?
MediHelp rates the interaction as moderate. Cyclizine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclizine is a sedating antihistamine with anticholinergic effects, and maprotiline shares these properties. Together they can cause excess drowsiness and anticholinergic effects such as dry mouth, constipation, urinary retention, blurred vision and confusion.
How serious is the interaction between Cyclizine and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn about sedation and avoid driving until tolerance is known. Monitor older patients for confusion, urinary retention and constipation, and use an alternative antiemetic if these occur.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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