Drug interactions
Cyclizine + Memantine-donepezil
Severity: Moderate
Cyclizine and Memantine-donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine has anticholinergic properties that oppose the action of donepezil. This may reduce its cognitive benefit and worsen confusion in patients with dementia.
What this interaction means in plain words
Cyclizine and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between muscarinic blockade and cholinesterase inhibition.
What to do
Avoid anticholinergic antiemetics where possible and choose a non-anticholinergic alternative. Monitor cognition if use is necessary.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Memantine-donepezil?
MediHelp rates the interaction as moderate. Cyclizine and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclizine has anticholinergic properties that oppose the action of donepezil. This may reduce its cognitive benefit and worsen confusion in patients with dementia.
How serious is the interaction between Cyclizine and Memantine-donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid anticholinergic antiemetics where possible and choose a non-anticholinergic alternative. Monitor cognition if use is necessary.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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