Drug interactions
Cyclizine + Metaxalone
Severity: Moderate
Cyclizine and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine is a sedating antihistamine with anticholinergic activity. With metaxalone, drowsiness and impaired alertness may be increased.
What this interaction means in plain words
Cyclizine and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Metaxalone belongs to Musculoskeletal.
Why it happens
Additive CNS depression from H1 antagonism and metaxalone sedation.
What to do
Monitor for oversedation and advise against driving or operating machinery if drowsy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Metaxalone?
MediHelp rates the interaction as moderate. Cyclizine and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclizine is a sedating antihistamine with anticholinergic activity. With metaxalone, drowsiness and impaired alertness may be increased.
How serious is the interaction between Cyclizine and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and advise against driving or operating machinery if drowsy.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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