Drug interactions
Cyclizine + Secobarbital
Severity: Moderate
Cyclizine and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine is a sedating antihistamine, and with a barbiturate it may cause excessive drowsiness and slowed reactions.
What this interaction means in plain words
Cyclizine and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Secobarbital belongs to Central Nervous System.
Why it happens
Additive CNS depression from H1 antagonism and barbiturate GABA-A potentiation.
What to do
Warn about driving and machinery use. Use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Secobarbital?
MediHelp rates the interaction as moderate. Cyclizine and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclizine is a sedating antihistamine, and with a barbiturate it may cause excessive drowsiness and slowed reactions.
How serious is the interaction between Cyclizine and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn about driving and machinery use. Use the lowest effective doses.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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