Drug interactions
Cyclizine + Thioridazine
Severity: Moderate
Cyclizine and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have sedative and anticholinergic effects, so together they can cause marked drowsiness, confusion, dry mouth, urinary retention and tachycardia. Cyclizine may also blunt the antipsychotic effect through central antagonism, which is poorly characterised. Impaired alertness increases the risk of falls and accidents.
What this interaction means in plain words
Cyclizine and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Thioridazine belongs to Central Nervous System.
Why it happens
Additive H1 antagonism, muscarinic blockade and CNS depression.
What to do
Monitor for sedation and anticholinergic effects, and consider a non-anticholinergic antiemetic if suitable. Counsel patients about driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Thioridazine?
MediHelp rates the interaction as moderate. Cyclizine and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have sedative and anticholinergic effects, so together they can cause marked drowsiness, confusion, dry mouth, urinary retention and tachycardia. Cyclizine may also blunt the antipsychotic effect through central antagonism, which is poorly characterised. Impaired alertness increases the risk of falls and accidents.
How serious is the interaction between Cyclizine and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and anticholinergic effects, and consider a non-anticholinergic antiemetic if suitable. Counsel patients about driving and alcohol.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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