Drug interactions
Cyclobenzaprine + Daridorexant
Severity: Moderate
Cyclobenzaprine and Daridorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclobenzaprine is sedating, and daridorexant is a hypnotic orexin antagonist. Combined use can add to CNS depression, impairing psychomotor performance and next-day alertness.
What this interaction means in plain words
Cyclobenzaprine and Daridorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Daridorexant belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Use the lowest effective doses and consider reducing the daridorexant dose. Counsel on next-day drowsiness and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyclobenzaprine and Daridorexant, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Daridorexant
Frequently asked questions
Can I take Cyclobenzaprine with Daridorexant?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Daridorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclobenzaprine is sedating, and daridorexant is a hypnotic orexin antagonist. Combined use can add to CNS depression, impairing psychomotor performance and next-day alertness.
How serious is the interaction between Cyclobenzaprine and Daridorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and consider reducing the daridorexant dose. Counsel on next-day drowsiness and driving.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
