Drug interactions
Cyclobenzaprine + Hydroxyzine
Severity: Moderate
Cyclobenzaprine and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are sedating with anticholinergic properties, so together they produce more drowsiness, dry mouth and confusion. Hydroxyzine can also prolong the QT interval, and cyclobenzaprine may add to this.
What this interaction means in plain words
Cyclobenzaprine and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Hydroxyzine belongs to Respiratory.
Why it happens
Additive CNS depression, anticholinergic effects and potential QT prolongation.
What to do
Avoid in older adults; otherwise use the lowest doses, counsel on drowsiness, and check ECG in patients with QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Cyclobenzaprine with Hydroxyzine?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are sedating with anticholinergic properties, so together they produce more drowsiness, dry mouth and confusion. Hydroxyzine can also prolong the QT interval, and cyclobenzaprine may add to this.
How serious is the interaction between Cyclobenzaprine and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in older adults; otherwise use the lowest doses, counsel on drowsiness, and check ECG in patients with QT risk factors.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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