Drug interactions
Cyclobenzaprine + Iloperidone
Severity: Moderate
Cyclobenzaprine and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and have anticholinergic and alpha-adrenergic effects, so combining them can add to drowsiness, dizziness, orthostatic hypotension and anticholinergic symptoms. Both can also prolong the QT interval to some degree, which may matter in patients with other arrhythmia risks.
What this interaction means in plain words
Cyclobenzaprine and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Iloperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression, antimuscarinic, alpha-blocking and QT-prolonging effects.
What to do
Monitor for sedation, orthostatic hypotension and anticholinergic effects, and consider ECG monitoring if other QT risk factors are present. Counsel patients on driving and fall risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Cyclobenzaprine with Iloperidone?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and have anticholinergic and alpha-adrenergic effects, so combining them can add to drowsiness, dizziness, orthostatic hypotension and anticholinergic symptoms. Both can also prolong the QT interval to some degree, which may matter in patients with other arrhythmia risks.
How serious is the interaction between Cyclobenzaprine and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, orthostatic hypotension and anticholinergic effects, and consider ECG monitoring if other QT risk factors are present. Counsel patients on driving and fall risk.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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