Drug interactions
Cyclobenzaprine + Midazolam
Severity: Moderate
Cyclobenzaprine and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midazolam and cyclobenzaprine both depress the central nervous system, so combination can produce deeper sedation and, at higher doses, respiratory depression. The effect is most important in procedural sedation and in older or frail patients.
What this interaction means in plain words
Cyclobenzaprine and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Midazolam belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A enhancement and cyclobenzaprine's sedative actions.
What to do
Reduce midazolam dose and titrate carefully, monitoring sedation depth, oxygen saturation and respiration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Midazolam?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midazolam and cyclobenzaprine both depress the central nervous system, so combination can produce deeper sedation and, at higher doses, respiratory depression. The effect is most important in procedural sedation and in older or frail patients.
How serious is the interaction between Cyclobenzaprine and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce midazolam dose and titrate carefully, monitoring sedation depth, oxygen saturation and respiration.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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