Drug interactions
Cyclobenzaprine + Nabilone
Severity: Moderate
Cyclobenzaprine and Nabilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclobenzaprine is a sedating muscle relaxant with anticholinergic and tricyclic-like properties, and nabilone adds drowsiness and tachycardia. The combination may cause excessive sedation, dizziness and impaired coordination.
What this interaction means in plain words
Cyclobenzaprine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Nabilone belongs to Gastrointestinal Tract.
Why it happens
Additive central nervous system depression and anticholinergic effects through pharmacodynamic synergy.
What to do
Use the lowest effective doses and monitor sedation and heart rate. Advise against driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Nabilone?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclobenzaprine is a sedating muscle relaxant with anticholinergic and tricyclic-like properties, and nabilone adds drowsiness and tachycardia. The combination may cause excessive sedation, dizziness and impaired coordination.
How serious is the interaction between Cyclobenzaprine and Nabilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and heart rate. Advise against driving and alcohol.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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