Drug interactions
Cyclobenzaprine + Rilpivirine
Severity: Moderate
Cyclobenzaprine and Rilpivirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rilpivirine at supratherapeutic doses prolongs the QT interval, and cyclobenzaprine, structurally related to tricyclic antidepressants, has been associated with QT prolongation and arrhythmia. Combined use may increase the risk of torsades de pointes, particularly with other risk factors.
What this interaction means in plain words
Cyclobenzaprine and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Rilpivirine belongs to Anti Virals.
Why it happens
Additive QT interval prolongation.
What to do
Obtain a baseline ECG in patients with cardiac risk factors, correct potassium and magnesium, and monitor for QT prolongation or palpitations.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Rilpivirine
- Carbamazepine + Rilpivirine Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Rilpivirine?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rilpivirine at supratherapeutic doses prolongs the QT interval, and cyclobenzaprine, structurally related to tricyclic antidepressants, has been associated with QT prolongation and arrhythmia. Combined use may increase the risk of torsades de pointes, particularly with other risk factors.
How serious is the interaction between Cyclobenzaprine and Rilpivirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG in patients with cardiac risk factors, correct potassium and magnesium, and monitor for QT prolongation or palpitations.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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