Drug interactions
Cyclopenthiazide + Digoxin
Severity: Moderate
Cyclopenthiazide and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can cause hypokalemia and hypomagnesemia, which sensitize the myocardium to digoxin. This raises the risk of digoxin-related arrhythmias even when digoxin levels are in the usual range.
What this interaction means in plain words
Cyclopenthiazide and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Diuretic-induced potassium and magnesium loss increases myocardial sensitivity to digoxin (pharmacodynamic synergism).
What to do
Monitor serum potassium and magnesium regularly and correct deficiencies promptly. Consider a potassium-sparing agent or supplementation and review digoxin levels if symptoms of toxicity occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Cyclopenthiazide with Digoxin?
MediHelp rates the interaction as moderate. Cyclopenthiazide and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can cause hypokalemia and hypomagnesemia, which sensitize the myocardium to digoxin. This raises the risk of digoxin-related arrhythmias even when digoxin levels are in the usual range.
How serious is the interaction between Cyclopenthiazide and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium regularly and correct deficiencies promptly. Consider a potassium-sparing agent or supplementation and review digoxin levels if symptoms of toxicity occur.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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