Drug interactions
Cyclopenthiazide + Sotalol
Severity: Major
Cyclopenthiazide and Sotalol: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can cause hypokalemia and hypomagnesemia, which increase the risk of QT prolongation and torsade de pointes in patients on sotalol.
What this interaction means in plain words
Cyclopenthiazide and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Diuretic-induced electrolyte depletion potentiates sotalol's QT-prolonging effect.
What to do
Monitor potassium and magnesium and replace deficits; obtain ECG monitoring of the QTc interval.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Cyclopenthiazide with Sotalol?
MediHelp rates the interaction as major. Cyclopenthiazide and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Thiazide diuretics can cause hypokalemia and hypomagnesemia, which increase the risk of QT prolongation and torsade de pointes in patients on sotalol.
How serious is the interaction between Cyclopenthiazide and Sotalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium and magnesium and replace deficits; obtain ECG monitoring of the QTc interval.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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